Figure 3.

Differential expression of DNA damage response-related genes between wild type and Fanconi anemia (FA)-deficient HIO. (a) Represented are all the significantly enriched gene categories affected by genes which were significantly differentially regulated between wt and FA-deficient HIO both after 12 and 48 h. (b) The functional categories of genes which were time point specifically (12 and 48 h post IR) differentially regulated in FA-deficient cells were further divided. (c) Represented are the top differentially upregulated and downregulated genes for the 12 and 48 h time point separately and the gene list of genes commonly up- or downregulated is presented in the Venn diagram.