Table A1.
Baseline characteristics of the study population.
| Parameters | Value (N and %, Mean ± Standard Deviation (SD) or Median and Range) |
|---|---|
| No. of patients | 465 |
| Age (years) | 63 (20–85) |
| Sex | |
| Female | 176 (37.85%) |
| Male | 289 (62.15%) |
| Side | |
| Left | 228 (49.03%) |
| Right | 237 (50.97%) |
| Tumor Site | |
| Precentral | 182 (39.14%) |
| Postcentral | 128 (27.53%) |
| Temporal + Insular | 155 (33.33%) |
| Intra-operative protocol | |
| CEUS + / 5-ALA + | 43 (9.25%) |
| CEUS - / 5-ALA + | 35 (7.53%) |
| CEUS + / 5-ALA - | 34 (7.31%) |
| CEUS - / 5-ALA - | 353 (75.91%) |
| Radiological Features | |
| Ependymal involvement (yes vs. no) | 143 vs. 322 (30.75% vs 69.25%) |
| Corpus Callosum involvement (yes vs. no) | 155 vs. 310 (33.33% vs 66.67%) |
| Necrotic-cystic component (yes vs. no) | 319 vs. 146 (68.60% vs 31.40%) |
| Midline shift (yes vs no) | 222 vs. 243 (47.74% vs 52.26%) |
| Preoperative Tumoral Volume computed on postcontrast T1-weighted images, cm3 | 31 (0.682–136) |
| Preoperative Tumoral Volume computed on T2-weighted images, cm3 | 65 (3–497) |
| Preoperative ΔT1/T2 MRI Index | 48.55 (1.13–100) |
| Residual tumor, cm3 | 0.959 (0–37.506) |
| EOR (continuous variable) | 95 (38–100) |
| EOR (categorical variable) | |
| EOR = 100% | 184 (39.57%) |
| 99% ≤ EOR ≤ 90% | 133 (28.6%) |
| 89% ≤ EOR ≤ 80% | 76 (16.34%) |
| EOR ≤ 79% | 72 (15.48%) |
| Biological Features | |
| MGMT methylation (yes vs no) | 290 vs. 175 (62.37% vs. 37.63%) |
| IDH 1/2 mutation (yes vs no) | 38 vs. 427 (8.17% vs. 91.83%) |
| Ki-67 | 25 (2-95) |
| Two-gene model | |
| MGMT met and IDH 1/2 mut | 27 (5.81%) |
| MGMT met and IDH 1/2 wt | 263 (56.56%) |
| MGMT unmet and IDH 1/2 mut | 10 (2.15%) |
| MGMT unmet and IDH 1/2 wt | 165 (35.48%) |
| Postoperative Protocol | |
| Stupp protocol | 345 (74.2%) |
| Stupp protocol + CWs | 60 (12.9 %) |
| Stupp interrupted for side effects | 60 (12.9 %) |
Features of the study population are described using means ± standard deviation or median and range for continuous variables, number of cases with relative percentages reported in parentheses for categorical variables. EOR = extent of resection; MRI = magnetic resonance image; preoperative ΔT1/T2 MRI Index = ratio between pre-operative tumoral volume on postcontrast T1-weighted and T2 weighted images; CWs = Carmustine Wafers; MGMT =O6-methylguanine-DNA methyl-transferase; IDH = isocitrate dehydrogenase.