Table 2.

The results of the multivariate analysis of the association between the HO-1 genotype and the clinical outcomes after transplantation (first part).

Variable		OS			DFS			TRM			Relapse
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
High-risk disease
Donor HO-1 genotype, A/T or A/A vs. T/T	0.72	0.50–1.04	0.08	0.64	0.44–0.93	0.02	0.66	0.36–1.19	0.16	0.83	0.51–1.35	0.44
Recipient HO-1 genotype, A/T or A/A vs. T/T	0.91	0.62–1.32	0.61	0.99	0.68–1.45	0.98	1.03	0.57–1.85	0.92	0.99	0.60–1.64	0.98
Recipient age	0.99	0.97-0.99	0.004	0.99	0.98–1.00	0.02	0.98	0.96–0.99	0.006
Standard-risk disease
Donor HO-1 genotype, A/T or A/A vs. T/T	1.05	0.71–1.54	0.80	0.91	0.56–1.47	0.70	1.04	0.59–1.82	0.89	0.71	0.40–1.22	0.20
Recipient HO-1 genotype, A/T or A/A vs. T/T	1.39	0.93–2.08	0.10	1.30	0.79–2.17	0.28	1.15	0.66–2.00	0.62	1.41	0.76–2.63	0.28
Recipient age	0.97	0.96–0.98	<0.001	1.00	0.97–1.01	0.24	0.96	0.94–0.98	0.11	0.91	0.56–1.47	0.70
Donor age							0.97	0.94–1.01	0.11	1.33	0.80–2.22	0.27
CMV-positive recipient	1.22	0.77–1.92	0.39	0.58	0.36–0.94	0.03	0.47	0.26–0.82	0.008
ABO major mismatch							1.04	0.54–200	0.90
ABO minor mismatch	0.59	0.39–0.88	0.01				0.50	0.28–0.89	0.02
ABO bidirectional							13513.5	5555.6–33333.3	<0.001
Male donor/female recipient										1.00	0.58–1.75	0.99
Female donor/male recipient				2.27	1.05–5.00	0.04				2.22	1.03–4.76	0.04

Abbreviations: TRM, transplant-related mortality; HR, hazard ratio; CI, confidence interval; HSCT, hematopoietic stem cell transplant.