Table 1.
Inhibition of CYP2B6 and CYP3A4 by DLA extracts, teas and phytochemicals.
| Phytochemical or Extract | CYP2B6 IC50 (µM) | CYP3A4 IC50 (µM) |
|---|---|---|
| DLAme | 6.07 ** | 4.93 # |
| DLAtea | 2.31 ** | 5.67 # |
| A. aframe | 7.89 ** | 5.18 # |
| A. afratea | 11.27 ** | 5.59 # |
| Arteannuin B | 9.36 ** | 12.33 # |
| Quercetin | 19.86 * | 4.59 # |
| Artemisinin | 27.75 | >600 |
| Chrysosplenol-D | 52.06 | 22.96 # |
| Chrysosplenetin | 74.67 | 21.68 # |
| Kaempferol | >600 | 33.84 # |
| Deoxyartemisinin | 110.86 | >600 |
| Camphor (+) | 119.01 | >600 |
| Artemisinic Acid | 122.83 | 239.5 # |
| Camphor (-) | 141.93 | >600 |
| Scopoletin | >600 | 410.19 # |
| Chlorogenic Acid | >600 | >600 |
* IC50 significantly lower than artemisinin; p ≤ 0.05; **p ≤ 0.0001; n = 3. # IC50 lower than artemisinin but no statistical difference determined because the artemisinin IC50 is higher than the highest tested concentration (600 µM).