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. 2020 Jan 24;9(2):288. doi: 10.3390/cells9020288

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme representation of proposal pathways regulated by melatonin in skeletal muscle. Notably, melatonin mechanisms of action involved mitochondria signaling. CAT: catalase; IL-6: interleukin-6; IGF1: insulin-like growth factor-1; LC3I/LC3II: microtubule-associated protein 1A/1B-light chain 3 free in the cytosol or conjugated to phosphotidylethanolamine during autophagy; NMJ: neuromuscular junction; NRF1 and NRF2: nuclear respiratory factor 1 and 2; PGC-1α: peroxisome proliferative activated receptor gamma coactivator-1alpha; ROS: reactive oxygen species; SIRT1: sirtuin1; SOD: superoxide dismutase; TFAM: mitochondrial transcription factor; TNFα: tumor necrosis factor alpha.