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. 2020 Feb 19;12(2):489. doi: 10.3390/cancers12020489

Figure 2.

Figure 2

Syk is also an upstream signalling molecule of EGFR in SCC. (A) EGF-induced phosphorylation of EGFR and downstream signalling molecules for 0, 15, 30, and 60 min after EGF (100 ng/mL) treatment compared to that of A431. Concentration-dependent EGF treatment (0, 10, 30, and 100 ng/mL) for 30 min in CAL27 and SAS cells. (B,C) Phosphorylation of EGFR and downstream signalling molecules after EGF (100 ng/mL) treatment with or without R406 (1 μM) for 0, 0.5, 1, 3, and 6 h in CAL27 (B) and SAS cells (C). Data are presented from three independent experiments.