Table 1.

Brief summary of ankyrin family proteins: ankyrin-R, ankyrin-B, ankyrin-G.

	Ankyrin-R	Ankyrin-B	Ankyrin-G
Tissue Expression	erythrocytes [1], myelinated axons [10], striated muscle [11]	ubiquitously expressed, cardiomyocytes (T-tubules, SR, plasma membrane) [12], neurons [8]	ubiquitously expressed, neurons (AIS, and nodes of Ranvier) [13], cardiomyocytes (intercalated disc) [14]
Examples of Binding Partners	CD44 [15], NKA [16], Rh type A glycoprotein [17], obscurin [11]	PP2A [12,13], NCX [12], NKA [18], Kir6.2 [12,13], CaV1.3 [19], βII-spectrin [20]	NaV1.6, βIV-spectrin, L1CAMs [1,21,22], plakophilin-2 [23] NaV1.5 [14]
Isoforms	sAnk1.5, 1.6, 1.7, and 1.9 [11]	AnkB-188 and AnkB-212 [24]. Giant AnkB (440-kD)	Giant AnkG (480-kD) [25]
Disease associated with variants	hereditary spherocytosis [26]	Ankyrin B syndrome: SCD, SND, AF, LQTS, VT, bradycardia, syncope [12], ARVC [27]	Brugada syndrome [12], dilated cardiomyopathy [28], cognitive disabilities [29]

SR = sarcoplasmic reticulum, AIS = axon initial segments, NKA = Na⁺/K⁺ ATPase, PP2A = protein phosphatase 2A, NCX = Na⁺/Ca²⁺ exchanger, Kir6.2 = inward rectifier potassium channel, Ca_V1.3 = voltage-gated calcium channel, L1CAMs = L1 family of neural cell adhesion molecules, SCD = sudden cardiac death, SND = sinus node disease, AF = atrial fibrillation, LQTS = long QT syndrome, VT = ventricular tachycardia, ARVC = arrhythmogenic right ventricular cardiomyopathy.