Figure 3.

Long noncoding RNA regulates lymphoid cell differentiation and function. Multiple lncRNAs are involved in lymphoid cell differentiation and regulate polarization and effector cell functions. (A,B) NeST and linc-MAF-4 interact with specific transcription factors and guide them to the IFNG and MAF-4 locus, respectively. This directly influences transcription of target genes and promotes the Th1 phenotype. (C) CCR2-5’ AS induces expression of various Th2 cytokines and facilitates GATA3 (critical Th2 transcription factor) function. (D) In resting CD8 cells, NRON sequesters a critical transcription factor NFAT. In activated T cells, calcineurin mediates dephosphorylation and nuclear translocation of NFAT. Green arrows denote transcriptional activation and red arrows denote transcriptional repression.