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. 2020 Feb 10;10(2):262. doi: 10.3390/biom10020262

Table 1.

MicroRNAs regulating cardiac regeneration through control of cardiomyogenesis.

ncRNA Model Disease Therapy Observed Effect Reference
miR-199a and miR-590 Neonatal mouse - AAV9-mediated OE CM proliferation ↑,
heart size ↑		 [76]
Adult mouse MI AAV9-mediated OE CM proliferation ↑, regeneration ↑, function ↑ [76]
miR-199a Pig MI AAV6-mediated OE CM proliferation ↑, contractility ↑, muscle mass ↑, scar size ↓, sudden arrhythmic death [10]
miR-195 Embryonic mouse - Transgenic cardiac OE Heart size ↓, CM proliferation ↓, ventricular defects [6]
Neonatal mouse MI Transgenic cardiac OE CM proliferation ↓, regeneration ↓, ventricular defects [78]
miR-15 family Neonatal mouse - AntimiR-mediated INH CM proliferation ↑ [6]
Neonatal/adult mouse MI AntimiR-mediated INH CM proliferation ↑, function ↑, regeneration ↑ [78]
Adult mouse MI AntimiR-mediated INH CM proliferation ↑, Infarct size ↓, function ↑, regeneration ↑ [79]
miR-128 Neonatal mouse - Transgenic cardiac OE CM proliferation ↓, function ↓ [80]
Neonatal mouse - Transgenic cardiac KO CM proliferation ↑, [80]
Adult mouse MI Transgenic cardiac KO CM proliferation ↑, Infarct size ↓, function ↑ [80]
miR-1 Embryonic mouse - Transgenic OE Ventricular defects, mortality ↑ [81]
Embryonic mouse - Transgenic OE CM proliferation ↓, ventricular defects [84]
miR-133 Zebrafish VR Transgenic OE Regeneration ↓ [86]
Zebrafish VR Sponge-mediated INH Regeneration ↑ [86]
Embryonic mouse - Transgenic double KO Ventricular defects, heart failure, mortality ↑ [85]
Embryonic mouse - Transgenic OE CM proliferation ↓, mortality ↑ [85]
miR-302-367 Neonatal mouse - Transgenic OE CM proliferation ↑ [87]
Adult mouse - Transgenic cardiac OE CM proliferation ↑, function ↓ [87]
Adult mouse MI Mimic-mediated OE CM proliferation ↑, Infarct size ↓, function ↑ [87]
miR-17-92 cluster Embryonic/neonatal mouse - Transgenic cardiac KO CM proliferation ↓, ventricular defects [89]
Embryonic/neonatal mouse - Transgenic cardiac OE CM proliferation ↑ [89]
Adult mouse MI Transgenic cardiac OE CM proliferation ↑, heart size ↑, infarct size ↓, function ↑ [89]
miR-99/100-Let-7 cluster Zebrafish VR Mimic-mediated OE CM proliferation ↓, regeneration ↓ [7]
Zebrafish VR AntimiR-mediated INH CM proliferation ↑, regeneration ↑ [7]
Mouse MI AAV-antimiR INH CM proliferation ↑, regeneration ↑, function ↑ [7]

AAV, Adeno-associated virus; CM, Cardiomyocyte; INH, Inhibition; KO, Knock-out; MI, Myocardial Infarction; OE, Overexpression; VR, Ventricular resection.