Table 1.
Physical characteristics of α- and β-emitting radionuclides used for RIT of PDAC.
| Half-Life | LET in Water (keV/µm) | Maximum Energy (MeV) | Maximum Range in Water (µm) | Number of PANC-1 Cells Traversed * | |
|---|---|---|---|---|---|
| A emitters | Maximum | ||||
| 225Ac | 9.92 d | 102 | 8.4 | 82.2 | 3.9 |
| 213Bi | 45.6 m | 102 | 8.4 | 82.2 | 3.9 |
| 212Pb | 10.6 h | 99.4 | 8.8 | 88.5 | 4.2 |
| Β emitters | Average | ||||
| 90Y | 2.67 d | 2.00 | 2.28 | 11400 | 570 |
| 177Lu | 6.65 d | 0.28 | 0.498 | 1800 | 125 |
| 131I | 8.02 d | 0.20 | 0.606 | 3032 | 202 |
* Calculated using the average cell diameter of a PANC-1 pancreatic cancer cell line of 20 µm. LET, linear energy transfer.