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. 2020 Jan 26;9(2):298. doi: 10.3390/cells9020298

Figure 1.

Figure 1

AKAP1 protein domain structure and sequence conservation. (A) Protein domain schematic of AKAP1 with the N-terminal OMM transmembrane at the left and the KH and Tudor domains at the C-terminus on the right. Included are some of the interacting proteins, CaN, PKA and PP1, and sites of post-translational modification by AMPK and caspases. The GLDRNEE repeat is expanded in many mammals, including humans, and it accounts for some of the variation in molecular weights across species. (B) Blocks represent the average conservation score of 10 residues and correspond to the diagram in (A). Block conservation was determined from the alignment of 113 orthologs using the ConSurf web server (http://consurf.tau.ac.il/). Abbreviations: AMPK, 5’ adenosine monophosphate-activated protein kinase; CaN, calcineurin; KH, K homology; PKA, protein kinase A; PP1, protein phosphatase 1; TM, transmembrane.