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. 2020 Feb 11;9(2):405. doi: 10.3390/cells9020405

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

TWEAK/Fn14 axis in cardiovascular disease. Schematic representation of TWEAK roles in pathological cardiovascular remodeling diseases. TWEAK in cardiovascular diseases (CVDs) affect inflammatory cells, cardiomyocytes, fibroblasts, endothelial and smooth muscle cells (SMCs) in CVDs. TWEAK/Fn14 axis interaction promotes pathological tissue remodeling; atherosclerosis (inflammation, lipid accumulation and plaque progression, and instability), restenosis (SMCs proliferation, migration, and cyclins regulation), heart failure (cardiomyocytes dysfunction and fibrosis), abdominal aortic aneurysm (inflammation, matrix degradation, AAA progression, angiogenesis).