Table 1.
Genes with a highly significant correlation between CNV and mRNA expression level, cellular localization of their proteins and their function.
| Gene Name | Chromosomal Locus 1 | CNV vs mRNA Pearson’s Correlation Coefficient 2 |
Protein Expression 3 | Protein Function (GeneCards 4) |
|---|---|---|---|---|
| CDKN1A | 6p21.2 | R = 0.4434, p = 0.0002 | nucleus | Cell cycle regulation |
| KLF6 | 10p15.2 | R = 0.5474, p < 0.0001 | nucleus | Transcriptional activator |
| FAM160B1 | 10q25.3 | R = 0.7632, p < 0.0001 | cytoplasm | unknown |
| PAOX | 10q26.3 | R = 0.6088, p < 0.0001 | cytoplasm | Polyamine oxidase |
| PWWP2B | 10q26.3 | R = 0.52, p < 0.0001 | cytoplasm | unknown |
| FBXW4 | 10q24.32 | R = 0.4296, p = 0.0003 | golgi | Ubiquitination |
| FBXL15 | 10q24.32 | R = 0.4048, p = 0.0007 | cytoplasm | Ubiquitination |
| CASKIN2 | 17q25.1 | R = 0.4364, p = 0.0002 | cytoplasm | unknown |
| RTN4RL1 | 17p13.3 | R = 0.4013, p = 0.0008 | secreted | Brain development |
| FMNL1 | 17q21.31 | R = 0.3974. p = 0.001 | cytoplasm | Regulation of cell morphology |
| RAB37 | 17q25.1 | R = 0.369, p = 0.002 | cytoplasm | GTPase |
| SOCS3 | 17q25.3 | R = 0.3611, p = 0.003 | cytoplasm | Cytokine signaling suppression |
| C21orf2 | 21q22.3 | R = 0.5435, p < 0.0001 | mitochondria | Regulation of cell morphology, DNA damage repair |