Table 2.
Tumor stage, histological grading according to necrosis and/or sarcomatoid differentiation, CDKN1A expression separated by the best separation cutoff from FIREHOSE [24] mRNA data and overall survival in chromophobe renal cell carcinoma.
| Cohort | TCGA-KICH | Swiss Patients | ||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Univariate | Multivariate2 | Univariate | Multivariate | ||||
| HR (95%CI) | p-value | HR (95%CI) | p-value | HR (95%CI) | p-value | HR (95%CI) | p-value | |
| Tumor stage (3–4 vs 1–2) 1 |
10.22 (2.12–49.29) | 0.004 | 6.442 (1.488–37.214) | 0.012 | 1.447 (0.398–5.264) | n.s. | 1.266 (0.343–4.678) | n.s. |
| Grade (High vs Low) |
18.03 (4.448–73.05) | <0.001 | 6.087 (1.374–32.266) | 0.017 | - | - | - | - |
| CDKN1A expression (Low vs High) 2, 3 |
22.528 (2.862–2904.443) | <0.001 | 12.527 (1.289–1675.059) | 0.026 | 4.812 (1.07–21.64) | <0.05 | 4.741 (1.051–21.390) | <0.05 |
HR, hazard ratio; CI, confidence interval; n.s.: not significant; 1 TCGA-KICH: T stage, Swiss patients: pT stage; 2 Firth correction was used because of quasi-complete separation; there was no event in one of the subgroups; 3 CDKN1A mRNA expression in TCGA-KICH cohort and CDKN1A protein expression in Swiss cohort.