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View full-text article in PMC

. 2020 Feb 8;9(2):394. doi: 10.3390/cells9020394

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Representative image of major ECM-integrin alterations in gastric cancer. ECM composition, as well as integrin expression and signaling, are distinct in normal and in gastric cancer contexts. Relevant players for gastric carcinogenesis are depicted to illustrate aberrant features. Briefly, during gastric cancer development, the expression of some integrin heterodimers is lost (α6β4), whereas that of others is increased (α2β1, α5β1, and αvβ6). Moreover, the increased activity of several MMPs (MMP-2, MMP-7, and MMP-9) is associated with cancer cell invasion. Increased levels of collagens (Col I and Col IV) and laminin γ2 are also part of a specific gastric cancer ECM signature.