Figure 1.

Loss of Werner Syndrome Protein (WRN) and WRNIP1 exacerbates genomic instability upon mild replication stress (MRS). (A) Co-IP analysis showing the interaction between WRN and WRNIP1 after IP with anti-FLAG antibody in HEK293T cell extracts, followed by Western blot with the indicated antibodies; (B) Analysis of chromosomal aberrations. Data are presented as chromosomal aberration per cell. Error bars represent standard error; (C) Alkaline comet assay in cells treated as in (B). Data are presented as tail moment ± SE from three independent experiments.