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. 2020 Feb 4;12(2):357. doi: 10.3390/cancers12020357

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Epigenetic drugs influence main post-translational modifications of the nucleosomal histones including deacetylation of lysine residues (HDACi), methylation (HMAs), reduction of H3K79 methylation (DOT1Li) and H3K27 (EZH2i), demethylation of lysine residues (LSD1i) and bromodomain, and extra-terminal motif inhibitor (BETi). Abbreviations: Me: Methylationl Ac: Acetylation; HDAC: Histone deacetylase; HMA: Hypomethylating agents; DOT1L: Disruptor of telomeric silencing 1-like; EZH2: Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit; LSD1: Lysine specific demethylase 1.