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Schematic representation of human phosphodiesterase genes. Phosphodiesterases (PDEs) are organized into 11 families with specific adenosine 3′5′-cyclic monophosphate (cAMP) and/or guanosine 3′5′-cyclic monophosphate (cGMP) substrates (identified on the right). CaM, calmodulin-binding domain; GAF, cGMP-binding PDEs Anabaena sp. adenylyl cyclase and Escherichia coli. FhlA; TM, transmembrane domain; REC, signal receiver domain; PAS, Per-Arnt-Sim domain; UCR, upstream conserved region.
