Table 1.
miRNA | Cellular Function | Target | Signaling Pathway | Cell Line | References | |
---|---|---|---|---|---|---|
1 | miRNA-105 | Promote metastasis | ZO-1 (tight junction protein) MXI1 |
|
MDA-MB-231 | [61,62,63,64] |
2 | miRNA-93 | EC glycolysis and EC proliferation | KLF2 and PFKFB3 (in glycolysis). FOXO1 and MYC (in proliferation). WNK lysine deficient protein kinase 1 (WNK1) ↓LATS2 |
|
MT-1 MDA-MB-231 Breast carcinoma specimens. |
[25,65] |
3 | miRNA-10b and miRNA-196b | Produced in response to tumor secreted VEGF and regulate EPC function and angiogenesis | ↓HOXD10 |
|
IDC grade III tumors | [66] |
4 | miRNA-155 | Up-regulates glucose transporters and glycolytic enzymes. Associated with poor prognosis and metastasis. | ↓VHL |
|
TNBC- late-stage (stage III/IV), lymph node metastasis | [67,68] |
5 | miRNA-4530 | Decreases proliferation, induces apoptosis, promotes angiogenesis | ↓VASH1 (endogenous angiogenesis inhibitor |
|
MCF-7 MDA-MB-231 HUVEC |
[69] |
6 | miRNA-153 | Response to high glucose Tumor suppressor EMT suppressor Down-regulated in BC |
IRE1α-XBP1 ↓MTDH |
|
MDA-MB-231 HCC1937 Luminal A and B, Basal, HER 2 positive |
[70,71] |
7 | miRNA-205 | Enhances chemosensitivity of breast cancer cells to TAC chemotherapy (docetaxol, doxorubicin plus cyclophosphamide) | ↓VEGFA and FGF2 |
|
MCF-7/A02 and CALDOX | [57] |
8 | miRNA-206 | Suppresses glycolysis | ↓VEGF PFKFB3 |
|
MDA-MB-231, MDA-MB-435, and HCC1395 | [72,73] |
9 | miRNA-221/222 | Anti-angiogenic Anti-proliferative Increases senescence Response to high glucose |
↓eNOS ↓ZEB2 ↓P27 |
|
Mouse microvascular endothelial cells (MMECs) | [74,75] |
10 | miRNA-100 | Mesenchymal stem cell derived exosomes | ↓VEGF |
|
MDA-MB-231, MCF-7, T47D, HUVEC BM-MSC |
[76] |
11 | miRNA-29b | Invasion, proliferation and migration | AKT3 SPIN1 |
|
HUVEC MDA-MB-231 |
[77] |
12 | miRNA-23a | Up/down-regulated in specific type of cancers. Aerobic glycolysis Anti-angiogenic |
↓LDHA and LDHB |
|
HUVEC | [78,79] |
13 | miRNA-23b | Inversely correlated with metastasis | ↓PAK2, MLC II Phosphorylation, under the regulation of AP-1, directly target cytoskeleton genes. JAM-C and ZO-2 |
|
MCF7 MDA-MB-231 HUVEC Xenograft |
[80,81,82] |
14 | miRNA-182 | Oncogenic | ↓FBXW7 |
|
hy926 MCF-7 ER and PR positive BC |
[83] |
15 | miRNA-497 | Down-regulated EMT | ↓VEGFR2, ↓VEGF and ↓HIF-1α ↓ Slug |
|
MCF-7 4T1 Xenograft Invasive ductal breast cancer |
[84,85,86] |
16 | miRNA-140-5p | Tumor suppressor | ↓VEGFA, ↓MMP9 |
|
MCF-7 MDA-MB-231 |
[11] |
17 | miRNA-467 | Response to hyperglycemia Tissue specific |
↓TSP-1 |
|
EMT6 (mu) C116 |
[87,88] |
18 | miRNA-126 | Endothelial cell specific | ↓VEGFA ↓PIK3R2 ↓SPRED1 |
|
MCF-7 | [89] |
19 | miRNA-27a | Pro-angiogenic | ↑ZBTB10 |
|
MDA-MB-231 BCSLCs (SK-3rd) |
[90] |
20 | miRNA-21 | Responsive to glucose level Pro-angiogenic Modulates ROS level Promotes metastasis |
↓PTEN and SMAD7 HIF-1α PDCD4, maspin LZTFL1 |
|
MCF-7 MDA-MB-231 |
[91,92,93,94,95,96,97,98] |
21 | miRNA-503 | Anti-angiogenic | ↓CCND1 |
|
MCF-7, T47D, MDA-MB231, BT549, SKBR3, ZR-75-30 | [99,100] |
22 | miRNA-34a | Response to high glucose | ↓SIRT1 |
|
BT-474, MDA-MB-231, MDA-MB-435, MDA-MB-468, SK-BR-3, EC |
[101,102,103] |
23 | miRNA-26a | ↓ VEGF dependent migration and proliferation Anti-angiogenic |
↓NgBR MCL-1 |
|
HUVECs MDA-MB-231, MCF-7, MDA-MB-435, MDA-MB-468 |
[104,105] |
24 | miRNA- 98 | Anti-angiogenic | ↓MMP11, ↓ALK4 |
|
4T1, MT1, MDA-MB-231, MDA-MB-468, Xenograft |
[106] |
25 | miRNA-126 | Response to high glucose ↓Type 2 diabetes |
↓VEGFA and PI3K regulatory subunit 2 (PIK3R2) CD97, GPCR |
|
MDA-MB-231 MCF-7 plasma from DM patients |
[59,60,107] |
26 | miRNA-145 | Anti-angiogenic | N-RAS and VEGF-A IGF-I/IRS |
|
MCF-7 MDA-MB-231 |
[108] |
27 | miRNA-20a | Predominantly in TNBC pro-angiogenic |
↑VEGFA and HIF-1α |
|
MCF-7 MDA-MB-231 |
[109] |
28 | miRNA-526b miRNA-655 |
Tumor associated angiogenesis and lymphangiogenesis | EP4, ↓PTEN and PI3K/Akt ↑VEGFA |
|
MCF-7 ER and PR positive HER 2 negative BC |
[46] |
29 | let-7a | Regulates key anabolic enzymes ROS production |
Stearol Co-A Desaturase (SCD) G6PD, FASN, BACH1 |
|
MDA-MB-231 | [110] |