Table 1.
PBX3-targetting microRNAs (miRs) in cancer. AML, acute myeloid leukemia; HCC, hepatocellular carcinoma; lncRNA, long non-coding RNA; MAP3K2, mitogen-activated protein kinase kinase2; MM, multiple myeloma; MMP11, matrix metalloprotease 11; UTR, untranslated region.
miR | Cancers | Binding/Other Targets/Regulation | Ref. |
---|---|---|---|
miR-let-7d | Prostate cancer | Upregulated by androgen | [14] |
miR-let-7c | Colorectal cancer | Binds 3’UTR, also targets MMP11 | [17] |
miR-let-7b | Glioma | Binds 3’UTR | [18] |
miR-181 | AML | Binds 3’UTR | [19] |
miR-129-5p | Pancreatic cancer | Binds 3’UTR | [20] |
miR-495 | AML and melanoma | Binds 3’UTR, also targets MEIS1 | [21] |
miR-200b | HCC and breast cancer | Binds 3’UTR | [23,24] |
miR-222 | HCC | Binds 3’UTR | [24] |
miR-424 | HCC | Binds 3’UTR | [24] |
miR-320a | MM, gastric cancer, and HCC | Binds 3’UTR | [25,26,27] |
miR-33a-3p | HCC | Binds 3’UTR | [28] |
miR-497 | MM | Binds 3’UTR | [29] |
miR-144-3p | Gastric cancer | Binds 3’UTR | [30] |
miR-98 | Glioma | Binds 3’UTR | [31] |
miR-144 | Lung cancer, HCC | Binds 3’UTR, also binds the lncRNA UCA1 | [32,33] |
miR-302a | HCC | Binds 3’UTR, also targets MAP3K2 | [34] |
miR-526b | Cervical cancer | Binds 3’UTR | [35] |