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. 2020 Feb 21;12(2):503. doi: 10.3390/cancers12020503

Figure 3.

Figure 3

Drug loading and releasing behaviors. The anticancer drug doxorubicin (Dox) was encapsulated into TPH and TPM polymeric mixed micelles. To optimize the drug loading efficiency, various amounts of the doxorubicin were in-feed and the drug contents and efficiency of TPH (a) and TPM mixed micelles (b) were determined by a UV-vis spectrum. Simultaneously, CD spectrum of TPH (c) and TPM (d) micelles were also detected. The drug releasing profiles of these mixed micelles at 37 °C in pH 7.4 and 4.0 conditions were also determined using a UV-vis spectrum (e). The CD spectrum of the mixed micelles after incubation at pH 7.4 and 4.0 conditions for 24 h were also investigated (f). Asterisk markers represent significant difference in statistics (**p < 0.01).