Table 2.
Stratified analysis of TGFβ polymorphisms and their association with BC risk.
| Model | Odds Ratio (OR) | 95% CI | p-Value | |
|---|---|---|---|---|
| TGF-β1 29C>T (Pro10Leu) or T869C or rs1982073 or rs1800470 | ||||
| Caucasian | ||||
| 1 | Overall allele C vs. T | 1.008 | 0.961–1.057 | 0.749 |
| 2 | Homozygous CC vs. TT | 1.007 | 0.907–1.120 | 0.891 |
| 3 | Heterozygous TC vs. TT | 1.038 | 0.990–1.088 | 0.123 |
| 4 | Recessive CC vs. TT + TC | 0.997 | 0.910–1.093 | 0.947 |
| 5 | Dominant CC + TC vs. TT | 1.039 | 0.994–1.086 | 0.093 |
| Asian | ||||
| 6 | Overall allele C vs. T | 1.058 | 0.952–1.176 | 0.298 |
| 7 | Homozygous CC vs. TT | 1.084 | 0.894–1.314 | 0.413 |
| 8 | Heterozygous TC vs. TT | 1.115 | 1.006–1.237 | 0.039 |
| 9 | Recessive CC vs. TT + TC | 1.055 | 0.875–1.271 | 0.576 |
| 10 | Dominant CC + TC vs. TT | 1.077 | 0.980–1.182 | 0.123 |
| European | ||||
| 11 | Overall allele C vs. T | 1.142 | 0.761–1.715 | 0.521 |
| 12 | Homozygous CC vs. TT | 1.466 | 0.516–4.116 | 0.473 |
| 13 | Heterozygous TC vs. TT | 1.319 | 0.536–3.247 | 0.547 |
| 14 | Recessive CC vs. TT + TC | 1.227 | 0.882–1.707 | 0.224 |
| 15 | Dominant CC + TC vs. TT | 1.355 | 0.552–3.312 | 0.505 |
| Middle Eastern | ||||
| 16 | Overall allele C vs. T | 0.833 | 0.625–1.110 | 0.212 |
| 17 | Homozygous CC vs. TT | 0.784 | 0.461–1.332 | 0.367 |
| 18 | Heterozygous TC vs. TT | 0.602 | 0.375–0.966 | 0.035 |
| 19 | Recessive CC vs. TT + TC | 1.011 | 0.632–1.618 | 0.964 |
| 20 | Dominant CC + TC vs. TT | 0.669 | 0.438–1.020 | 0.062 |
| TGFβ-1-509 C/T or -1349C>T or rs1800469 | ||||
| Caucasian | ||||
| 21 | Overall allele T vs. C | 0.953 | 0.905–1.004 | 0.068 |
| 22 | Homozygous TT vs. CC | 0.904 | 0.803–1.018 | 0.096 |
| 23 | Heterozygous CT vs. CC | 0.957 | 0.891–1.028 | 0.228 |
| 24 | Recessive TT vs. CC + CT | 0.924 | 0.825–1.036 | 0.175 |
| 25 | Dominant TT + CT vs. CC | 0.947 | 0.885–1.031 | 0.112 |
| European | ||||
| 26 | Overall allele T vs. C | 1.016 | 0.900–1.148 | 0.795 |
| 27 | Homozygous TT vs. CC | 1.039 | 0.770–1.401 | 0.804 |
| 28 | Heterozygous CT vs. CC | 1.038 | 0.950–1.135 | 0.405 |
| 29 | Recessive TT vs. CC + CT | 1.026 | 0.782–1.346 | 0.853 |
| 30 | Dominant TT + CT vs. CC | 1.058 | 0.972–1.151 | 0.190 |
| Asian | ||||
| 31 | Overall allele T vs. C | 1.023 | 0.925–1.132 | 0.657 |
| 32 | Homozygous TT vs. CC | 1.000 | 0.813–1.230 | 0.990 |
| 33 | Heterozygous CT vs. CC | 1.633 | 0.894–2.986 | 0.111 |
| 34 | Recessive TT vs. CC + CT | 0.993 | 0.842–1.171 | 0.936 |
| 35 | Dominant TT + CT vs. CC | 1.460 | 0.886–2.408 | 0.138 |
| TGF-β *6A or rs11466445 | ||||
| European | ||||
| 36 | Overall allele 6A vs. 9A | 1.095 | 0.878–1.364 | 0.421 |
| 37 | Homozygous 6A/6A vs. 9A/9A | 1.247 | 0.749–2.075 | 0.396 |
| 38 | Heterozygous 6A/9A vs. 9A/9A | 1.056 | 0.809–1.378 | 0.690 |
| 39 | Recessive 6A/6A vs. 9A/9A + 9A/6A | 1.249 | 0.751–2.077 | 0.391 |
| 40 | Dominant 6A/6A + 9A/6A vs. 9A/9A | 1.049 | 0.839–1.311 | 0.675 |