Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 23;9(2):283. doi: 10.3390/cells9020283

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Directed differentiation of human pluripotent stem cells (hPSCs) into pancreatic progenitors and beta cells. Left panel, pancreatic progenitors co-expressing the transcription factors, PDX1 and NKX6.1, are considered bona fide beta cell precursors and can be differentiated with a high efficiency from optimized in vitro protocols [21]. Right panel, hPSC-derived pancreatic beta cells expressing INS alone (monohormonal) (arrows) or INS and GCG (polyhormonal) (arrowheads) (Abdelalim’s lab, unpublished data). PSCs, Pluripotent stem cells; DE, Definitive endoderm; PG, Posterior gut tube; PFG, Posterior foregut; PP, Pancreatic progenitors; EP, Endocrine progenitors; PDX1, Pancreatic and duodenal homeobox 1; NKX6.1, NK6 homeobox 1; INS, INSULIN; GCG, GLUCAGON.