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. 2020 Feb 12;10(2):283. doi: 10.3390/biom10020283

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of nAChR function by various acylcholines. (A) Inhibition curves for AA-CHOL (red line, squares), Ol-CHOL (blue line, triangles), Ln-CHOL (black line, diamonds), and DHA-CHOL (green line, circles) of Ca²⁺ influx evoked by acetylcholine in the presence of PNU 120596 on SH-SY5Y cell line. The IC₅₀ values are listed in Table 2; (B) ACh evoked current in the mouse muscle nAChR expressed in Xenopus oocyte is inhibited by AA-CHOL at low micromolar concentrations (IC₅₀ 3.16 ± 0.26 μM).