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. 2020 Feb 7;12(2):385. doi: 10.3390/cancers12020385

Figure 3.

Figure 3

Ex vivo BLI is useful to detect small metastatic colonies. (A,B) In a human neuroblastoma xenograft mouse model (LAN-1-Luc2/mCherry cells), early BM colonies became apparent 50 days after tumor cell injection (21 days after resection of the xenograft tumor) by ex vivo BLI (despite missing bone-related BLI signals in vivo). TB = trabecular bone; for further abbreviations, please see legend to Figure 2.