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. 2020 Feb 21;9(2):498. doi: 10.3390/cells9020498

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the role in cholangiocarcinoma of uptake (up) and export (down) transporters as biomarkers for diagnosis and prediction of response to chemotherapy (left) or as targets for strategies of chemosensitization to antitumor drugs (right). Aquaporin-1/5 (AQP-1/5); apical sodium-dependent bile acid transporter (ASBT); cooper transporter (CTR1); equilibrative nucleoside transporter 1 (ENT1); glucose transporter 1/2 (GLUT1/2); L-type amino acid transporter-1 (LAT1); multidrug resistance protein 1 (MDR1); multidrug resistance-associated protein 1/3 (MRP1/3); sodium–iodide symporter (NIS); organic cation transporter 1 (OCT1); Phosphohippolin (PPH); sodium-dependent vitamin C transporter 2 (SVCT2).