Table 4.
KIR gene and genotype frequencies in CRC patients and healthy controls.
| Healthy Controls | CRC Cases | ||||||
|---|---|---|---|---|---|---|---|
| KIR Gene | n | % | n | % | p-value * | Pbonf | OR (95% CI) |
| KIR2DL1 | 1075 | 99.91 | 942 | 99.89 | NS | NS | |
| KIR2DL2 | 490 | 45.54 | 418 | 44.33 | NS | NS | |
| KIR2DL3 | 925 | 85.97 | 818 | 86.74 | NS | NS | |
| KIR2DL4 | 1076 | 100 | 943 | 100 | NS | NS | |
| KIR2DL5 | 500 | 46.47 | 450 | 47.72 | NS | NS | |
| KIR3DL1ex4 | 1030 | 95.72 | 911 | 96.61 | NS | NS | |
| KIR3DL1ex9 | 1032 | 95.91 | 911 | 96.61 | NS | NS | |
| KIR3DL2 | 1076 | 100 | 943 | 100 | NS | NS | |
| KIR2DS1 | 386 | 35.87 | 346 | 36.69 | NS | NS | |
| KIR2DS2 | 530 | 49.26 | 480 | 50.9 | NS | NS | |
| KIR2DS3 | 350 | 32.53 | 370 | 39.24 | 0.002 | 0.036 | 1.34 (1.12–1.61) |
| KIR2DS4total | 1030 | 95.72 | 909 | 96.39 | NS | NS | |
| KIR2DS4wt | 366 | 34.01 | 306 | 32.45 | NS | NS | |
| KIR2DS4del | 905 | 84.11 | 801 | 84.94 | NS | NS | |
| KIR2DS5 | 286 | 26.58 | 257 | 27.25 | NS | NS | |
| KIR3DS1 | 337 | 31.32 | 319 | 33.83 | NS | NS | |
| KIR2DP1 | 1074 | 99.81 | 943 | 100 | NS | NS | |
| KIR3DP1 | 1076 | 100 | 943 | 100 | NS | NS | |
| KIR Genotype | n | % | n | % | p-value * | OR (95% CI) | |
| AA | 280 | 26.02 | 243 | 26.77 | NS | ||
| Bx | 796 | 73.98 | 700 | 74.23 | NS | ||
NS: not significant; OR: odds ratio; CI: confidence interval. Pbonf: P value using Bonferroni correction. * Two-tailed Fisher’s exact test.