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. 2020 Feb 17;9(2):453. doi: 10.3390/cells9020453

Figure 6.

Figure 6

The protective effect of iPSC-EV was related to the modulation of anti-oxidative stress genes in renal tissue. The analysis performed using Ingenuity pathway analysis (IPA) showed (a) the enriched biological processes associated with the modulated genes by iPSC-EV administration, indicated in the horizontal bars and ordered by their significance. (b) IPA network analysis generated by the modulated genes by iPSC-EV in renal tissue interconnected with relevant nodes involved in the most representative biological pathways associated with the EV treatment. qRT-PCR analysis of mRNA levels of (c) superoxide dismutase 1 (SOD1), (d) aldehyde oxidase-1 (AOX1), (e) significantly up-regulate sirtuin 1 (SIRT1), and (f) SIRT2 in renal tissue expressed as relative quantification (RQ) with respect to IRI (SHAM, n = 3; IRI, n = 3; IRI+iPSC-EV, n = 5; IRI+ASC-EV, n = 3). Data represent mean ± SEM (* indicates statistical difference to SHAM group; # indicates statistical difference to IRI group; ** indicates statistical difference to IRI+iPSC-EV group; p <0.05 assessed by one-way ANOVA followed by Tukey’s test).