Table 1.
Genes modulated by iPSC-EV treatment during IRI and associated with oxidative stress in renal tissue (iPSC-EV with respect to IRI).
| Fold Change with respect to IRI | Symbol | Gene Name | Location |
|---|---|---|---|
| 13.0 | RAG2 | recombination activating 2 | Nucleus |
| 8.6 | NOXA1 | NADPH oxidase activator 1 | Plasma Membrane |
| 3.5 | UCP3 | uncoupling protein 3 | Cytoplasm |
| 2.7 | NGB | neuroglobin | Cytoplasm |
| 2.1 | Mpo | myeloperoxidase | Extracellular Space |
| 1.8 | Hba-a2/Hba1 | hemoglobin, alpha 1 | Cytoplasm |
| 1.8 | AOX1 | aldehyde oxidase 1 | Cytoplasm |
| 1.8 | DUOX2 | dual oxidase 2 | Plasma Membrane |
| 1.7 | GPX6 | glutathione peroxidase 6 | Extracellular Space |
| 1.7 | TPO | thyroid peroxidase | Plasma Membrane |
| 1.7 | SOD1 | superoxide dismutase 1 | Cytoplasm |
| 1.6 | NOX4 | NADPH oxidase 4 | Cytoplasm |
| 1.6 | ERCC6 | ERCC excision repair 6, chromatin remodeling factor | Nucleus |
| 1.6 | PTGS1 | prostaglandin-endoperoxide synthase 1 | Cytoplasm |
| 1.6 | CYBA | cytochrome b-245 alpha chain | Cytoplasm |
| 1.6 | CCL5 | C-C motif chemokine ligand 5 | Extracellular Space |
| 1.6 | EHD2 | EH domain containing 2 | Nucleus |
| 1.6 | PSMB5 | proteasome subunit beta 5 | Cytoplasm |
| 1.6 | TXNRD2 | thioredoxin reductase 2 | Cytoplasm |
| 1.5 | SLC38A1 | solute carrier family 38 member 1 | Plasma Membrane |
| 1.5 | SOD3 | superoxide dismutase 3 | Extracellular Space |
| 1.5 | EPX | eosinophil peroxidase | Cytoplasm |
| 1.5 | PARK7 | Parkinsonism associated deglycase | Nucleus |
| 1.5 | TXN | thioredoxin | Cytoplasm |
| 1.5 | GSTK1 | glutathione S-transferase kappa 1 | Cytoplasm |
| −1.6 | NOXO1 | NADPH oxidase organizer 1 | Plasma Membrane |
| −1.6 | GSTP1 | glutathione S-transferase pi 1 | Cytoplasm |
| −1.8 | GPX5 | glutathione peroxidase 5 | Extracellular Space |
| −1.9 | ALB | albumin | Extracellular Space |
| −3.0 | LPO | lactoperoxidase | Extracellular Space |
| −8.0 | NOS2 | nitric oxide synthase 2 | Cytoplasm |
| −11.1 | DUOX1 | dual oxidase 1 | Plasma Membrane |
| −11.4 | MB | myoglobin | Cytoplasm |
| −21.5 | HSPA1A/HSPA1B | heat shock protein family A (Hsp70) member 1A | Cytoplasm |