Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 11;21(4):1180. doi: 10.3390/ijms21041180

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Molecular structures of slow H₂S-releasing agents with potential anti-inflammatory properties for the treatment of arthritis. ADT-OH (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) and ATB-429 ([4-(5-sulfanylidenedithiol-3-yl) phenyl] 5-amino-2-hydroxybenzoate) are H₂S-releasing derivatives of mesalamine. ATB-337, ATB- 343, and ATB-345 are respectively diclofenac, indomethacin, and naproxen linked to a hydrogen sulfide-releasing moiety. ATB-346 is naproxen covalently linked to 4-hydroxythiobenzamide (TBZ). ACS-14 is aspirin linked to H₂S donors, ACS-21 is deacetylated aspirin linked to H₂S donors, and NBS1120 is a NO H₂S-releasing derivative of aspirin. GYY4137—morpholin-4-ium 4 methoxyphenyl phosphinodithioate; DAS—diallyl sulfide.