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(a,d) Monomeric Aβ42, Aβ40, and Aβ42/Aβ40 in conditioned medium, (b,e) neurotoxicity, and (c,f) toxic Aβ42 oligomers in lysate from human iPS-derived neurons treated with (a,b,c) 1 and (d,e,f) bryo-1 at the indicated concentration (0, 1, 3, 10, 30, 100, 300, and 1000 nM from left to right) for 24 h. The data are presented as mean ± SEM (n = 3).
