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. 2020 Feb 17;9(2):451. doi: 10.3390/cells9020451

Figure 1.

Figure 1

Effects of the mitochondrial antioxidant MitoQ (MQ) on cardiac interstitial fibrosis, superoxide anion levels and cardiac 18-FDG uptake in obese rats. Hearts from rats fed a standard diet (CT) or a high fat diet (HFD) treated with vehicle or with MQ (200 µM) were analyzed. (A) Quantification of collagen volume fraction (CVF) and (B) representative microphotographs of sections stained with picrosirius red. (C) Quantification of total cardiac levels of superoxide anion and (D) representative microphotographs of cardiac sections labeled with DHE. (E) Quantification of myocardial 18-FDG uptake and (F) Representative photographs of 18F-Fluorodeoxyglucose (FDG) PET/CT scans in trans-axial views scaled to standardized uptake value (SUV). Magnification (×40).Bar graphs represent the mean ± SEM. of 6–8 animals. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. control group. † p < 0.05; †† p < 0.01; ††† p < 0.001 vs. HFD group.