Eag1	SK	TRPV5/6	KCNQ
CaM Docking	N-lobe	N1 (holo) [23,24]	S4-S5 (holo) [45]	C1 (holo) [79,80,81]	hB (holo) [117]
	C-lobe	C1, C2 (holo) [23]	hA (apo) [45]	C2 (holo) [79,80,81]	hA (apo) [117]
Ca2+ signaling		C-lobe [30]	N-lobe [45]	EF3/4 linker [79,80,81]	C-lobe [85,97,121]
Residence/motility	N-lobe	Dynamic [25]	Dynamic [45]	Dynamic [75]	Static [85,97,121]
	C-lobe	Dynamic [25]	Static [45]	Dynamic [75]	Partially static [85,97,121]
Mechanism		Allosteric(S4/5, PAS cap) [20]	Mechanical (ViSD, S4/5a) [45]	Direct pore [75]	Indirect (PIP2, S6 gate) [97,121]
EC50 Ca2+		70–100 nM [25,29]	440 nM [50]	90 nM [67]	?
Ca2+ Effect		Inhibition [25,29]	Activation [39]	Blockade [79,80,81]	?