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Disruption of the microtubule network suppresses the activation of NLRP3 inflammasome. ELISA of IL-1β in culture supernatants of LPS-primed bone marrow-derived macrophages (BMDMs) pretreated with or without microtubule or actin disruptors followed by (A) NLRP3, (B) AIM2 or NLRP4 inflammasome inducers. n = 3 independent experiments per group. Data represent the mean ± SD. Statistical analyses were performed using one-way ANOVA with Turkey’s multiple comparisons. **, p < 0.01.
