Table 3.
Biodistribution of [125I]I-PIB-(HE)3-ZHER3:08698-DOTAGA and [111In]In-(HE)3-ZHER3:08698-DOTAGA in Balb/c nu/nu mice bearing BxPC3 xenografts at 4 and 24 h pi. Uptake is presented as percent of injected dose per gram (%ID/g). Results are presented as average ± SD of four mice.
| Organ | 4 h | 24 h | ||
|---|---|---|---|---|
| [125I]I-PIB | [111In]In | [125I]I-PIB | [111In]In | |
| Blood | 0.37 ± 0.05 a,b | 0.06 ± 0.01 c | 0.05 ± 0.01 | 0.019 ± 0.002 |
| Salivary glands | 0.18 ± 0.01 a,b | 1.1 ± 0.1 c | 0.02 ± 0.01 | 0.78 ± 0.07 |
| Lung | 0.49 ± 0.06 a,b | 0.9 ± 0.2 c | 0.04 ± 0.01 | 0.31 ± 0.03 |
| Liver | 0.32 ± 0.04 a,b | 3.3 ± 0.6 c | 0.05 ± 0.01 | 2.1 ± 0.4 |
| Spleen | 0.12 ± 0.01 a,b | 0.5 ± 0.2 c | 0.027 ± 0.004 | 0.21 ± 0.02 |
| Stomach | 0.22 ± 0.04 a,b | 1.3 ± 0.1 c | 0.02 ± 0.01 | 0.7 ± 0.1 |
| Small intestine | 0.30 ± 0.07 a,b | 3.7 ± 0.8 c | 0.02 ± 0.02 | 1.6 ± 0.2 |
| Kidney | 2.7 ± 0.7 a,b | 291 ± 39 c | 0.15 ± 0.02 | 211 ± 28 |
| Tumor | 0.8 ± 0.1 a,b | 2.4 ± 0.1 c | 0.06 ± 0.04 | 1.7 ± 0.1 |
| Muscle | 0.05 ± 0.02 a,b | 0.14 ± 0.02 c | 0.008 ± 0.002 | 0.07 ± 0.01 |
| Bone | 0.4 ± 0.3 | 0.3 ± 0.1 c | 0.07 ± 0.02 | 0.10 ± 0.02 |
Differences were significant (p < 0.05) between: a the uptake of (HE)3-ZHER3:08698-DOTAGA labeled with [125I]I-PIB and [111In]In at the same time point (paired t-test); b the uptake of [125I]I-PIB-(HE)3-ZHER3:08698-DOTAGA at 4 and 24 h (unpaired t-test); c the uptake of [111In]In-(HE)3-ZHER3:08698-DOTAGA at 4 and 24 h (unpaired t-test).