Figure 2.

Gene-set enrichment analysis of deregulated genes in SHS-exposed mice. We performed gene ontology analysis on the 153 unique genes identified in SHS-exposed mice, before and after recovery, relative to controls. (A) Eighteen genes are specifically implicated in hepatic steatosis. Red and green nodes represent up-regulated and down-regulated genes, respectively. (B) The Functional Clustering Analysis tool in DAVID was used to group together redundant annotations. The top ten categories identified by DAVID, with a group enrichment score between 1.26 and 3.88 (x-axis), are listed on the y-axis. (C) The top canonical pathways and hepatotoxic functions were displayed along with the significance values and number of associated molecules and included, among others, liver steatosis, inflammation and necrosis.