. 2020 Feb 14;21(4):1296. doi: 10.3390/ijms21041296

Table 1.

List of differentially expressed genes (n = 153) identified in the liver of SHS-exposed mice, both before and after recovery time, relative to controls.

Expression ¹ Log Ratio	ID	D ²	Symbol ³	Entrez Gene Name	Location
3.543	1426037_a_at	D	RGS16 *	regulator of G-protein signaling 16	Cytoplasm
3.466	1422557_s_at	D	Mt1	metallothionein 1	Cytoplasm
3.26	1428942_at		Mt2	metallothionein 2	Other
3.245	1417168_a_at	D	USP2	ubiquitin specific peptidase 2	Cytoplasm
2.943	1422257_s_at	D	CYP2B6	cytochrome P450 family 2 subfamily B member 6	Cytoplasm
2.387	1442025_a_at	D	ZBTB16	zinc finger and BTB domain containing 16	Nucleus
2.265	1418288_at	D	LPIN1 *	lipin 1	Nucleus
2.221	1427747_a_at		LCN2	lipocalin 2	Extracellular Space
2.174	1428223_at		MFSD2A *	major facilitator superfamily domain containing 2A	Plasma Membrane
2.168	1443147_at	D	ACOT1 *	acyl-CoA thioesterase 1	Cytoplasm
2.095	1416125_at		FKBP5	FK506 binding protein 5	Nucleus
1.956	1435188_at		CIART	circadian associated repressor of transcription	Nucleus
1.933	1425837_a_at		NOCT *	nocturnin	Nucleus
1.922	1451190_a_at	D	SBK1	SH3 domain binding kinase 1	Other
1.87	1428923_at		PPP1R3G	protein phosphatase 1 regulatory subunit 3G	Cytoplasm
1.864	1451548_at	D	UPP2	uridine phosphorylase 2	Cytoplasm
1.774	1460241_a_at	D	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Cytoplasm
1.759	1419590_at		Cyp2b13/Cyp2b9	cytochrome P450, family 2, subfamily b, polypeptide 9	Cytoplasm
1.707	1416432_at		PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Cytoplasm
1.61	1429144_at	D	GPCPD1	glycerophosphocholine phosphodiesterase 1	Cytoplasm
1.598	1434437_x_at	D	RRM2	ribonucleotide reductase regulatory subunit M2	Nucleus
1.594	1416933_at		POR *	cytochrome p450 oxidoreductase	Cytoplasm
1.542	1439489_at		FFAR4 *	free fatty acid receptor 4	Plasma Membrane
1.542	1448162_at		VCAM1	vascular cell adhesion molecule 1	Plasma Membrane
1.523	1429206_at		RHOBTB1	Rho related BTB domain containing 1	Other
1.518	1453023_at		ANKHD1/ANKHD1-EIF4EBP3	ankyrin repeat and KH domain containing 1	Other
1.493	1434473_at		SLC16A5	solute carrier family 16 member 5	Plasma Membrane
1.492	1417761_at	D	APOA4	apolipoprotein A4	Extracellular Space
1.469	1417602_at		PER2	period circadian clock 2	Nucleus
1.45	1425824_a_at		PCSK4	proprotein convertase subtilisin/kexin type 4	Extracellular Space
1.437	1448239_at		HMOX1 *	heme oxygenase 1	Cytoplasm
1.433	1452416_at		IL6R	interleukin 6 receptor	Plasma Membrane
1.418	1427473_at		Gstm3	glutathione S-transferase, mu 3	Cytoplasm
1.403	1449851_at		PER1	period circadian clock 1	Nucleus
1.38	1417904_at		DCLRE1A	DNA cross-link repair 1A	Nucleus
1.336	1450505_a_at	D	FAM134B	family with sequence similarity 134, member B	Cytoplasm
1.334	1440840_at		SLC16A7	solute carrier family 16 member 7	Plasma Membrane
1.302	1423233_at		CEBPD	CCAAT/enhancer binding protein delta	Nucleus
1.296	1416773_at		WEE1	WEE1 G2 checkpoint kinase	Nucleus
1.279	1435459_at	D	FMO2	flavin containing monooxygenase 2	Cytoplasm
1.279	1426452_a_at		RAB30	RAB30, member RAS oncogene family	Cytoplasm
1.268	1421681_at	D	NRG4	neuregulin 4	Extracellular Space
1.259	1435495_at		ADORA1 *	adenosine A1 receptor	Plasma Membrane
1.251	1426850_a_at		MAP2K6	mitogen-activated protein kinase kinase 6	Cytoplasm
1.247	1421852_at		KCNK5	potassium two pore domain channel subfamily K member 5	Plasma Membrane
1.246	1443870_at		ABCC4	ATP binding cassette subfamily C member 4	Plasma Membrane
1.242	1422230_s_at		CYP2A6 (includes others)	cytochrome P450 family 2 subfamily A member 6	Cytoplasm
1.239	1458442_at		AI132709	expressed sequence AI132709	Other
1.238	1424175_at		TEF	TEF, PAR bZIP transcription factor	Nucleus
1.231	1424744_at		SDS	serine dehydratase	Cytoplasm
1.213	1434292_at		Snhg11	small nucleolar RNA host gene 11	Other
1.212	1418780_at		CYP39A1	cytochrome P450 family 39 subfamily A member 1	Cytoplasm
1.207	1453410_at		ANGPTL4	angiopoietin like 4	Extracellular Space
1.199	1456156_at		LEPR	leptin receptor	Plasma Membrane
1.198	1449565_at		Cyp2g1	cytochrome P450, family 2, subfamily g, polypeptide 1	Cytoplasm
1.198	1449498_at		MARCO	macrophage receptor with collagenous structure	Plasma Membrane
1.197	1428352_at		ARRDC2	arrestin domain containing 2	Other
1.185	1418595_at		PLIN4	perilipin 4	Cytoplasm
1.178	1417042_at		SLC37A4	solute carrier family 37 member 4	Cytoplasm
1.169	1426980_s_at		EPOP	elongin BC and polycomb repressive complex 2 associated protein	Other
1.164	1445574_at	D	PPARGC1B *	PPARG coactivator 1 beta	Nucleus
1.162	1429809_at		TMTC2	transmembrane and tetratricopeptide repeat containing 2	Cytoplasm
1.152	1455958_s_at		PPTC7	PTC7 protein phosphatase homolog	Cytoplasm
1.151	1431339_a_at	D	EFHD2	EF-hand domain family member D2	Other
1.142	1428512_at		BHLHB9	basic helix-loop-helix domain containing, class B, 9	Cytoplasm
1.141	1455002_at	D	PTP4A1	protein tyrosine phosphatase type IVA, member 1	Cytoplasm
1.133	1428926_at	D	FBXO31	F-box protein 31	Extracellular Space
1.123	1416286_at		RGS4	regulator of G-protein signaling 4	Cytoplasm
1.115	1432543_a_at		KLF13	Kruppel like factor 13	Nucleus
1.111	1434456_at		RUNDC3B	RUN domain containing 3B	Other
1.108	1435860_at		SLC5A6	solute carrier family 5 member 6	Plasma Membrane
1.102	1427912_at		CBR3	carbonyl reductase 3	Cytoplasm
1.098	1456395_at	D	PPARGC1A *	PPARG coactivator 1 alpha	Nucleus
1.091	1454799_at		GPAT3	glycerol-3-phosphate acyltransferase 3	Cytoplasm
1.047	1419758_at		ABCB1	ATP binding cassette subfamily B member 1	Plasma Membrane
1.04	1423627_at		NQO1	NAD(P)H quinone dehydrogenase 1	Cytoplasm
1.036	1438211_s_at		DBP	D-box binding PAR bZIP transcription factor	Nucleus
1.032	1424815_at		GYS2	glycogen synthase 2	Cytoplasm
1.021	1448568_a_at		SLC20A1	solute carrier family 20 member 1	Plasma Membrane
1.007	1428487_s_at	D	COQ10B	coenzyme Q10B	Cytoplasm
1.007	1420772_a_at		TSC22D3 *	TSC22 domain family member 3	Nucleus
1.006	1433816_at		SLC25A51	solute carrier family 25 member 51	Cytoplasm
−1.003	1439377_x_at		CDC20	cell division cycle 20	Nucleus
−1.006	1455293_at		LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component	Nucleus
−1.008	1431056_a_at		LPL *	lipoprotein lipase	Cytoplasm
−1.013	1450010_at		HSD17B12	hydroxysteroid 17-beta dehydrogenase 12	Cytoplasm
−1.022	1417292_at		Ifi47	interferon gamma inducible protein 47	Cytoplasm
−1.022	1417792_at		ZNF638	zinc finger protein 638	Nucleus
−1.027	1452445_at		SLC41A2	solute carrier family 41 member 2	Plasma Membrane
−1.036	1448986_x_at		DNASE2	deoxyribonuclease 2, lysosomal	Cytoplasm
−1.037	1436931_at		RFX4	regulatory factor X4	Nucleus
−1.039	1450035_a_at	D	PRPF40A	pre-mRNA processing factor 40 homolog A	Nucleus
−1.04	1428022_at		OBP2B *	odorant binding protein 2B	Extracellular Space
−1.042	1427356_at		FAM89A	family with sequence similarity 89 member A	Other
−1.042	1424033_at		SRSF7	serine and arginine rich splicing factor 7	Nucleus
−1.043	1457758_at		ENY2	ENY2, transcription and export complex 2 subunit	Nucleus
−1.045	1416403_at		ABCB10	ATP binding cassette subfamily B member 10	Cytoplasm
−1.047	1450846_at		BZW1	basic leucine zipper and W2 domains 1	Cytoplasm
−1.048	1438713_at		RASSF8	Ras association domain family member 8	Extracellular Space
−1.051	1433515_s_at	D	ETNK1	ethanolamine kinase 1	Cytoplasm
−1.057	1437864_at		ADIPOR2 *	adiponectin receptor 2	Plasma Membrane
−1.057	1451122_at	D	IDI1	isopentenyl-diphosphate delta isomerase 1	Cytoplasm
−1.061	1425206_a_at		UBE3A	ubiquitin protein ligase E3A	Nucleus
−1.073	1420379_at		Slco1a1	solute carrier organic anion transporter family, member 1a1	Plasma Membrane
−1.077	1448183_a_at		HIF1A	hypoxia inducible factor 1 alpha subunit	Nucleus
−1.085	1452030_a_at		HNRNPR	heterogeneous nuclear ribonucleoprotein R	Nucleus
−1.085	1428372_at		ST5	suppression of tumorigenicity 5	Cytoplasm
−1.086	1450484_a_at		CMPK2	cytidine/uridine monophosphate kinase 2	Cytoplasm
−1.091	1431024_a_at		ARID4B	AT-rich interaction domain 4B	Nucleus
−1.108	1417832_at		SMC1A	structural maintenance of chromosomes 1A	Nucleus
−1.109	1424842_a_at		ARHGAP24	Rho GTPase activating protein 24	Cytoplasm
−1.11	1455324_at	D	PLCXD2	phosphatidylinositol specific phospholipase C X domain containing 2	Other
−1.12	1426458_at		SLMAP	sarcolemma associated protein	Plasma Membrane
−1.128	1438269_at		ZBTB38	zinc finger and BTB domain containing 38	Nucleus
−1.131	1449931_at		CPEB4	cytoplasmic polyadenylation element binding protein 4	Plasma Membrane
−1.136	1442537_at		CYP2U1	cytochrome P450 family 2 subfamily U member 1	Cytoplasm
−1.158	1449854_at		NR0B2	nuclear receptor subfamily 0 group B member 2	Nucleus
−1.16	1427574_s_at		SH3D19	SH3 domain containing 19	Plasma Membrane
−1.165	1435775_at		CLOCK	clock circadian regulator	Nucleus
−1.169	1429772_at	D	PLXNA2	plexin A2	Plasma Membrane
−1.171	1437932_a_at		CLDN1	claudin 1	Plasma Membrane
−1.172	1423325_at		PNN	pinin, desmosome associated protein	Plasma Membrane
−1.18	1447927_at	D	GBP6	guanylate binding protein family member 6	Cytoplasm
−1.205	1425099_a_at		ARNTL *	aryl hydrocarbon receptor nuclear translocator like	Nucleus
−1.208	1444512_at		ARHGAP29	Rho GTPase activating protein 29	Cytoplasm
−1.238	1442367_at		ATP11C	ATPase phospholipid transporting 11C	Plasma Membrane
−1.27	1417982_at		INSIG2 *	insulin induced gene 2	Cytoplasm
−1.275	1427513_at		BC024137	cDNA sequence BC024137	Other
−1.276	1430896_s_at		NUDT7	nudix hydrolase 7	Cytoplasm
−1.289	1450090_at		Zfp101	zinc finger protein 101	Nucleus
−1.295	1449514_at		GRK5	G protein-coupled receptor kinase 5	Plasma Membrane
−1.325	1421092_at		SERPINA12	serpin family A member 12	Cytoplasm
−1.343	1423571_at		S1PR1	sphingosine-1-phosphate receptor 1	Plasma Membrane
−1.346	1420531_at		Hsd3b4 (includes others)	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4	Cytoplasm
−1.354	1422769_at	D	SYNCRIP	synaptotagmin binding cytoplasmic RNA interacting protein	Nucleus
−1.379	1437581_at		ZNF800	zinc finger protein 800	Other
−1.395	1430785_at	D	SDR9C7	short chain dehydrogenase/reductase family 9C member 7	Other
−1.402	1426215_at		DDC *	dopa decarboxylase	Cytoplasm
−1.405	1426645_at		HSP90AA1	heat shock protein 90 alpha family class A member 1	Cytoplasm
−1.434	1433446_at	D	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1	Cytoplasm
−1.472	1423397_at		UGT2B28	UDP glucuronosyltransferase family 2, member B28	Cytoplasm
−1.482	1424709_at	D	SC5D	sterol-C5-desaturase	Cytoplasm
−1.509	1450264_a_at		CHKA	choline kinase alpha	Cytoplasm
−1.554	1438751_at		SLC30A10	solute carrier family 30 member 10	Other
−1.573	1417065_at		EGR1	early growth response 1	Nucleus
−1.58	1433944_at		HECTD2	HECT domain E3 ubiquitin protein ligase 2	Cytoplasm
−1.622	1431817_at		Adh6-ps1	alcohol dehydrogenase 6 (class V), pseudogene 1	Other
−1.663	1439300_at	D	CHIC1	cysteine rich hydrophobic domain 1	Plasma Membrane
−1.666	1427347_s_at	D	TUBB2A	tubulin beta 2A class IIa	Cytoplasm
−1.692	1450018_s_at	D	SLC25A30	solute carrier family 25 member 30	Cytoplasm
−1.896	1448092_x_at	D	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	Other
−2.034	1420722_at		ELOVL3	ELOVL fatty acid elongase 3	Cytoplasm
−2.382	1421447_at	D	ONECUT1	one cut homeobox 1	Nucleus

¹ A “positive” (+) fold ratio indicates up-regulation while a “negative” (−) fold ratio indicates down-regulation; ² D, duplicate transcripts were identified for that gene; ³ genes involved in lipid metabolism (n = 63) are indicated in bold. The asterisk (*) marks genes known to play a role in liver steatosis.