Table 4.

Risk of bone events and severe thrombocytopenia with MG.

	Risk of Bone Events								Risk of Severe Thrombocytopenia
			Univariate Analysis			Multivariable Analysis					Univariate Analysis			Multivariable Analysis
	n	Events	HR	95%CI	p	HR	95%CI	p	n	Events	HR	95%CI	p	HR	95%CI	p
MG §	150	61	1.40	0.69–2.86	0.353	1.28	0.60–2.75	0.525	151	36	0.58	0.14–2.42	0.453	0.55	0.12–2.47	0.439
Age at GD diagnosis	150	61	1.01	1.00–1.03	0.097	1.01	0.99–1.03	0.326	151	36	1	0.98–1.02	0.917	1.01	0.98–1.03	0.666
Male sex	150	61	1.04	0.62–1.73	0.713	1.28	0.73–2.23	0.525	151	36	0.96	0.50–1.86	0.906	0.81	0.41–1.60	0.548
Splenectomy during follow-up §	150	61	2.30	1.37–3.87	0.002	2.60	1.49–4.55	0.001	151	36	0.53	0.22–1.25	0.148	0.46	0.19–1.11	0.085
Treatment during follow-up *§	150	61	1.22	0.70–2.14	0.479	1.44	0.81–2.57	0.218	151	36	0.6	0.24–1.46	0.261	0.56	0.23–1.38	0.207

Survival was calculated from the time of GD diagnosis to the first occurrence of bone events or severe thrombocytopenia, or the last follow-up visit. GD: Gaucher disease; MG: monoclonal gammopathy; HR: hazard ratios; 95%CI: 95% confidence interval; * Treatment included enzyme replacement therapy or substrate reduction therapy. ^§ Time-dependent variables.