Table 2.

Animal models for Mucopolysaccharidosis type II. HR: homologous recombination.

Year of Publication	Animal Model	Model Generation	Reference
1998	Dog	Spontaneous (genetic analysis not available)	[220]
1999	Mouse	Knock-out: substitution of exon 4 and part of exon 5 by HR with the neomycin resistance gene	[19,218]
2010	Mouse	Knock-out: substitution of 1485 bp of exon 2 and exon 3 by HR with the neomycin resistance gene	[165]
2010	Zebrafish	Knock-down by antisense morpholino oligo against the ATG translation initiation site	[221]
2012	Mouse	Knock-out: deletion from exon 2 to exon 5 (JCR Pharmaceuticals Co.)	[222]
2016	Mouse	Knock-out: deletion from exon 2 to exon 5 (Taconic Biosciences #TF1838)	[166]
2018	Zebrafish	Knock-out: deletion of 5 bp in the exon 2 by CRISPR/Cas9 approach	[200]