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. 2020 Feb 19;21(4):1398. doi: 10.3390/ijms21041398

Table 1.

Summary of exosomal miRNA studies in CRC patients.

miRNA Number of
CRC
Patients*		 Sample Type Exosome
Isolation
Method		 Expression Type of Biomarker Refs
miR-16,
miR-23a-3p, miR-23b-3p, miR-27a-3p, miR-27b-3p, miR-30b, miR-30c, and miR-222		 13 Serum and plasma Ultracentrifugation Upregulated Diagnostic [85]
miR-96
and
miR-149		 102 plasma ExoCapTM exosome isolation and enrichment kit downregulated Diagnostic [87]
miR-23a and miR-301a 25 serum ExoQuick upregulated Diagnostic [91]
miR-17,
miR-181a, miR-18a, and miR-18b		 18 plasma ExoQuick upregulated diagnostic [90]
miR-320d 142 serum ultracentrifugation upregulated Diagnostic [92]
miR-125a and miR-320c 50 plasma ExoQuick upregulated Diagnostic [89]
miR-92b 40 plasma ultracentrifugation downregulated Diagnostic [88]
let-7a, miR-1229, miR-1246, miR-150, miR-21, miR-223, and miR-23a 88 serum ultracentrifugation upregulated Diagnostic [93]
miR-6869 142 serum Invitrogen Total Exosome Isolation Kit downregulated Prognostic [94]
miR-146a 53 serum Ultracentrifugation,
ExoQuick		 upregulated Prognostic [95]
miR-1229 97 serum ultracentrifugation upregulated Prognostic [96]
miR-19a 227 serum Invitrogen Total Exosome Isolation Kit upregulated Prognostic [97]
miR-21 326 plasma ultracentrifugation Upregulated Prognostic [98]
miR-25-3p 75 serum ultracentrifugation upregulated Prognostic [99]
miR-4772-3p 84 serum ExoQuick downregulated Prognostic [100]
miR-17, miR-18a, miR-18b, miR-19a, miR-19b, miR-20a, miR-20b and miR-106a 100 plasma ExoQuick upregulated Prognostic [101]
miR-193a 25 plasma Ultracentrifugation,
exoEasy Maxi Kit 		upregulated Prognostic [102]
miR-17 and miR-92a-3p 29 serum Ultracentrifugation and qEV Size Exclusion Columns upregulated Prognostic [103]
miR-203 240 serum ultracentrifugation upregulated Prognostic [104]
miR-21,
miR-1246,
miR-1229, and miR-96		 43 serum Ultracentrifugation, Invitrogen Total Exosome Isolation Kit, western blot upregulated Predictive [105]
miR-548c 108 serum Invitrogen Total Exosome Isolation Kit downregulated Diagnostic and Prognostic [106]
miR-27a and miR-130a 369 plasma Invitrogen Total Exosome Isolation Kit upregulated Diagnostic and Prognostic [107]
miR-6803 168 serum Invitrogen Total Exosome Isolation Kit upregulated Diagnostic and Prognostic [108]
miR-221 158 serum Ultracentrifugation upregulated Diagnostic and Prognostic [109]
miR-150 133 serum ExoQuick downregulated Diagnostic and Prognostic [110]
miR-196b 150 serum exoRNeasy Serum/Plasma Maxi Kit upregulated Prognostic, and Predictive [111]
miR-125b 61 plasma ultracentrifugation upregulated Prognostic, and predictive [112]

* number of CRC patients who had blood samples drawn which were utilized for exosomal analysis.