Figure 2.

Representative Western blots (above) and analyses of the protein expression (below) in endothelial cells grown with 100 nM PRAV or 100 nM ATOR (A) and in mitochondria isolated from ATOR-treated cells (B). CS: citrate synthase; COXII: cytochrome c oxidase subunit II; VDAC 1: voltage-dependent anion-selective channel protein 1; HKI: hexokinase I; HMGCR: HMG-CoA reductase; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; SOD2: superoxide dismutase 1; UCP2: uncoupling protein 2; ACADS: acyl-coenzyme A dehydrogenase; CoQ10B: mitochondrial coenzyme Q-binding protein CoQ10 homolog B; CI–CIV: complexes of respiratory chain. Mean ± SD; n = 5–10; p < 0.05 (*), comparison vs. control values.