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. 2020 Feb 19;21(4):1409. doi: 10.3390/ijms21041409

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of BAG3 p.P209L on DNAJB6. (A) Coexpression with BAG3 p.P209L similarly blocks the turnover of wild-type and p.F89I mutant DNAJB6b. Graph shows mean ± S.D. from 4–5 experiments performed in triplicate, with exponential trendlines fitted to the data points. (B) Representative Western blots showing DNAJB6b-V5 wt and p.F89I (V5) and tubulin (tub) levels at different time points. (C) Both DNAJB6a and DNAJB6b are recruited to cytoplasmic aggregates formed by BAG3 p.P209L in HeLa cells. (D) BAG3 p.P209L causes increased cytoplasmic localization of DNAJB6a in HeLa cells. Box plots show the cytoplasmic/nuclear V5 mean intensity ratio in n = 552–2291 cells per group.