Table 1.
Chaperone and cochaperone genes currently known to underlie neuromuscular disorders.
| Gene Symbol | Neuromuscular Disorder(s) (MIM1 Number When Available) |
|---|---|
| BAG3 | MFM6 (#612954); CMD1HH (#613881); CMT2 |
| CCT5 | Hereditary sensory neuropathy with spastic paraplegia (#256840) |
| CRYAB | MFM2 (#608810); CMD1II (#615184); Fatal infantile hypertonic myofibrillar myopathy (#613869) |
| DNAJB2 | DSMA5 (#614881); CMT2 |
| DNAJB6 | LGMD D1 DNAJB6-related (#603511); Distal myopathy with rimmed vacuoles |
| HSPB1 | dHMN2B (#608634); CMT2F (#606595) |
| HSPB3 | dHMN2C (#613376); CMT2; (neuro)myopathy |
| HSPB8 | dHMN2A (#158590); CMT2L (#608673); Neuromyopathy with rimmed vacuoles |
| HSPD1 | Spastic paraplegia 13, autosomal dominant (#605280) |
| SACS | Spastic ataxia, Charlevoix–Saguenay type (#270550) |
| SIL1 | Marinesco–Sjögren syndrome (#248800) |
| STUB1 | Spinocerebellar ataxia, autosomal recessive 16 (#615768) |
| TOR1A | Torsion dystonia, early onset (#128100) |
| VCP | Scapuloperoneal muscular dystrophy and dropped head syndrome; Distal myopathy; IBMPFD (# 167320); ALS14 (#613954); CMT2Y (#616687) |
| VMA21 | X-linked myopathy with excessive autophagy (XMEA) (#310440) |
1 MIM, Mendelian Inheritance in Man (www.omim.org).