Table 1.
Chondrocyte catabolism and apoptosis during age-induced and meniscectomy (MNX)-induced OA.
| Catabolic and Apoptotic Changes | 14-Month-Old Mice, Age-Induced OA | 3-Month-Old Mice, MNX-Induced OA | ||||
|---|---|---|---|---|---|---|
| WT | Gal3−/− | p | WT | Gal3−/− | p | |
| %ADAMTS5 + cells | 15.7 (9.3–17.7) | 27.3 (23.5–55.9) | 0.049 | 16.9 (11.8–21.0) | 26.9 (21.0–38.1) | 0.008 |
| %VDIPEN + cells | NA | NA | NA | 30.4 (12.6–34.7) | 56.1 (44.0–58.9) | 0.004 |
| %TUNEL + cells | 25.5 (22.5–29.5) | 45.2(32.5–45.6) | 0.049 | 18.3 (11.7–24.0) | 39.6 (34.0–42.5) | 0.008 |
The mean ratio [min, max] of femoral and tibia chondrocytes positively stained were shown. ADAMTS: a disintegrin and metalloprotease with thrombospondin-like repeat; VDIPEN: metalloproteinases-generated neoepitope; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling. NA: not assessed. Two-tailed Mann–Whitney U test between WT and Gal3−/−.