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. 2020 Feb 20;21(4):1441. doi: 10.3390/ijms21041441

Figure 6.

Figure 6

Failure of UCL-2077 to perturb the activity of BKCa channels functionally expressed in GH3 cells. In these experiments, inside-out current recordings were made, cells were bathed in high-K+, Ca2+-free solution, bath solution contained 0.1 μM Ca2+ and the examined cell was held at +60 mV. (A) Original BKCa-channel currents obtained in the absence (a) and presence (b) of 10 μM UCL-2077. The upward deflection is the opening event of the channel. (B) Bar graph depicting effects of UCL-2077 (10 μM) and UCL-2077 (10 μM) plus PF1022A (10 μM) on the probabilities of BKCa channels that would be actively open (mean ± SEM, n = 8 for each bar). * denotes significant difference from control (p < 0.05).