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Percentage of elevation of IgG, IgM, and IgA antibodies against aquaporin-4 (AQP4) in 94 patients positive for ANCA and in 94 healthy controls. Dotted lines indicate the cutoff for positivity used in each assay, as calculated by ROC analysis. The percentage of elevation is indicated on top of each distribution, while bars indicate the corresponding median. The AUC for AQP4 IgG was 0.81, 0.74 for AQP4 IgM, and 0.81 for AQP4 IgA.
