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. 2020 Feb 19;21(4):1404. doi: 10.3390/ijms21041404

Table 3.

Analysis of the inhibition of DYRK1A-ΔC activity by ECG and EGCG as a function of ATP concentrations.

Compound DYRK1A-ΔC Remaining Activity With 200 µM ATP (%) DYRK1A-ΔC Remaining Activity with 400 µM ATP (%) DYRK1A-ΔC Remaining Activity with 800 µM ATP (%)
ECG (10 µM) 8.0 ± 0.8
(n = 4)
6.5 ± 0.9
(n = 4)
4.0 ± 0.5
(n = 4)
EGCG (10 µM) 11.0 ± 3.1
(n = 4)
9.6 ± 2.1
(n = 4)
5.4 ± 1.3
(n = 4)

Inhibition of DYRK1A-ΔC activity obtained with 10 μM of ECG and EGCG in the presence of different concentrations of ATP (200–800 μM) is shown. Assays were run for up to 60 min at 37 °C.