Table 3.
Compound | DYRK1A-ΔC Remaining Activity With 200 µM ATP (%) | DYRK1A-ΔC Remaining Activity with 400 µM ATP (%) | DYRK1A-ΔC Remaining Activity with 800 µM ATP (%) |
---|---|---|---|
ECG (10 µM) | 8.0 ± 0.8 (n = 4) |
6.5 ± 0.9 (n = 4) |
4.0 ± 0.5 (n = 4) |
EGCG (10 µM) | 11.0 ± 3.1 (n = 4) |
9.6 ± 2.1 (n = 4) |
5.4 ± 1.3 (n = 4) |
Inhibition of DYRK1A-ΔC activity obtained with 10 μM of ECG and EGCG in the presence of different concentrations of ATP (200–800 μM) is shown. Assays were run for up to 60 min at 37 °C.