Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 18;21(4):1384. doi: 10.3390/ijms21041384

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Concentration–response curves to (A) Cmpd17b in the presence of DMSO (control), L-NAME (NOS inhibitor), Indo (non-selective COX inhibitor), L-NAME+Indo, or LNAME+Indo+KCaB (inhibitors of K_Ca3.1 and K_Ca2.x channels) in the aorta of male mice. Concentration–response curves to Cmpd17b in (B) endothelium intact and endothelium denuded aorta or (C) in the presence of 50mM K⁺, ODQ (soluble guanylate cyclase inhibitor) or glibenclamide (ATP-sensitive potassium channel blocker). Concentration–response curves to (D) CaCl₂ in aorta treated with control (DMSO), Cmpd17b, or nifedipine (calcium channel blocker). * P < 0.05, significantly different to control. Values are expressed as mean ± SEM, n = 3–12 per group. Sensitivity (pEC₅₀), maximum relaxation (R_max), and maximum constriction (E_max) values are shown in Table 1.