Figure 5.

Concentration–response curves to (A) ACh, (B) SNP, and (C) Cmpd17b in the aorta of citrate buffer (normal) or streptozotocin (diabetic)-treated male mice with or without Cmpd17b. Concentration–response curves and to ACh in the presence or absence of Indo (non-selective COX inhibitor) or Indo+L-NAME (NOS inhibitor) in the aorta of citrate buffer (normal) (D), streptozotocin (diabetic) (E), or streptozotocin (diabetic) and Cmpd17b (F) treated male mice. Values are expressed as mean ± SEM, n = 4–8 per group. Sensitivity (pEC₅₀) and maximum relaxation (R_max) values are shown in Table 2. P < 0.05 significantly different from pEC₅₀ values in (*) normal mice or (#) diabetic mice. ^ P < 0.05 significantly different from pEC₅₀ values in control within the same treatment group.