Table 2.
Vascular reactivity of aorta isolated from of mice treated with citrate buffer (control), STZ (diabetic), or STZ and Cmpd17b (diabetic+Cmpd17b).
| Drug | Sample Size | Control | Sample Size | Diabetic | Sample Size | Diabetic +Cmpd17b | |||
|---|---|---|---|---|---|---|---|---|---|
| ACh | n | pEC50 | Rmax | n | pEC50 | Rmax | n | pEC50 | Rmax |
| Control | 6 | 7.09 ± 0.07 | 92 ± 1 | 9 | 6.70 ± 0.06 * | 88 ± 2 | 7 | 7.11 ± 0.11 # | 90 ± 2 |
| Indo | 7 | 6.97 ± 0.12 | 91 ± 1 | 7 | 6.82 ± 0.12 | 88 ± 3 | 7 | 6.68 ± 0.11^ | 86 ± 2 |
| Indo+L-NAME | 7 | ND | 9 ± 4^ | 9 | ND | 13 ± 6^ | 8 | ND | 11 ± 8 ^ |
| SNP | n | pEC50 | Rmax | n | pEC50 | Rmax | n | pEC50 | Rmax |
| Control | 7 | 7.55 ± 0.11 | 95 ± 1 | 7 | 7.80 ± 0.12 | 96 ± 1 | 7 | 7.58 ± 0.08 | 94 ± 1 |
| Cmpd17b | n | pEC50 | Rmax | n | pEC50 | Rmax | n | pEC50 | Rmax |
| Control | 6 | 5.12 ± 0.13 | 70 ± 5 | 4 | 5.14 ± 0.13 | 67 ± 5 | ND | ND | ND |
Values are expressed as mean ± S.E.M; n, aorta from individual mice. ACh, acetylcholine; Indo, indomethacin; L-NAME, Nω-nitro-L-arginine methyl ester; SNP, sodium nitroprusside; pEC50, sensitivity; Rmax, maximum relaxation. ND = not determined. * Significantly different from control treated group; # significantly different from diabetic group; ^ Rmax significantly different from control and Indo incubated aorta within the same treatment group.